沈雷

发布时间:2019.01.16 14:49

沈雷  男  1983年2月生  理学博士  教授  硕/博士生导师

Tel15926376089

Emailleishen@whut.edu.cn

个人经历:

1999-2003,中国科学技术大学,化学物理专业,本科

2003-2008,中国科学技术大学&加拿大多伦多大学,博士(联培),导师:吴奇院士&Prof. Mitchell A. Winnik

2008-2009,瑞士日内瓦大学,博士后,合作导师:Michal Borkovec教授

2009-2012,美国德州大学&明尼苏达大学,博士后,合作导师:Xiaoyang Zhu教授&Timothy Lodge教授

2012-2013,美国哥伦比亚大学,化学系,助理研究员

2013-2016,华中科技大学,化学与化工学院,副教授

2017-现在,武汉理工大学,化学化工与生命科学学院,教授

研究方向:

大分子界面材料

研究特色:

瞄准生命健康,结合实验与计算模拟,揭示大分子微观分子机制,设计制备生物功能材料,如人工血管、缝合器械、血管支架、透析膜、敷贴、药物等。例如,阐明蛋白分子及细胞在材料表面的动态学特征及规律,在此基础上首创无涂层式一体化小口径(直径<4mm)人工血管,有良好的生物相容性、力学性、顺应性、可灭菌性、畅通性,安全无毒,无免疫原性,可为临床应用提供可靠的人工血管制备;阐明蛋白与药物分子作用的动态机制,在此基础上创制高效抗菌促愈合伤口敷贴;发明与血管相关手术器械,降低临床操作难度和相关并发症等。

课程教学:

主讲物理化学、高分子化学物理。

通过教学和科研一体化,从物理化学的基础理论和科学实验相结合,吸引本科生和研究生参加实验,培养的研究生获国家级一等奖学金、校三好学生和优秀毕业生等称号,指导的本科生多次获国家级省级以及校级竞赛一、二等奖。

欢迎喜欢大分子材料的你加入课题组!

主持科研项目及获得荣誉:

1.国家自然科学基金面上项目,2022-2025

2.国家自然科学基金面上项目,2015-2019

3.国家自然科学基金青年项目,2014-2016

4.武汉理工大学"15551"青年拔尖人才计划,2019-2024

5.湖北省人才计划,2015,高分子化学与物理

6.武汉理工大学第十届青年教师教学竞赛,2020,二等奖

7.武汉理工大学第二届教师教学创新大赛,2022,特等奖

申报国家发明专利:

1.一种人工血管材料及利用其制备的无涂层式一体化抗凝血小口径人工血管,202211281212.22022

2.一种吻合器,202222743945.52022

3.一种高效抗菌促愈合纳米纤维伤口敷料的制备及其应用,中国专利,2022

4.一种多糖微凝胶的制备方法,中国专利,201510326329.12015

5.Loading quantum dots into thermo-responsive microgels by reversible transfer from organic solvents to water. 美国专利,US7914710 B22011

近期代表性论文:

在专业核心期刊上发表学术论文60余篇,包括化学领域内顶尖期刊JACSMacromoleculesACS Macro Lett.LangmuirNano Lett.等,他引1700余次,研究工作多次被ACS Macro Lett., Langmuir, Soft Matter编辑邀请以封面发表,多次被审稿人和国际同行亮点评述,在国际权威胶体界面化学综述期刊Adv. Colloid Interface Sci.和国内高分子核心刊物《高分子学报》撰写综述评论文章。

1.Guanbin Gao*, X. Liu, Z. Gu, Q. Mu, G. Zhu, T. Zhang, C. Zhang, L. Zhou, Lei Shen*, Taolei Sun*. Engineering Nanointerfaces of Au25-Clusters for Chaperone-Mediated Peptide Amyloidosis. Nano Lett. 2022, 22, 2964.

2.L. Wen, Lei Shen*. Effect of Surface-Chelated Cu2+ on Amyloid-β Peptide Fibrillation. Langmuir, 2022, 38, 174.

3.Y. Song, Y. Geng, Lei Shen*. Visualizing Super-Diffusion, Oligomerization and Fibrillation of Amyloid-β Peptide Chains along Tubular Membranes ACS Macro Lett. 2021, 10, 1295. (Invited as Cover work)

4.X. Zhou, M. Zhao, Y. Y. Liu, Q. J. Chen, Lei Shen*. Statistical Binding Matching Between Influenza-A-Virus and Dynamic Glycan Clusters Determines Its Adhesion onto Lipid Membranes. Langmuir, 2020, 36, 15212. (Invited as Cover work)

5.M. Tian, B. Li*, Lei Shen*. Hierarchical Self-Assembly Mechanism of Ladder-Like Orientated Aβ40 Single-Stranded Protofibrils into Multistranded Mature Fibrils. ACS Macro Lett. 2020, 9, 1759. (Invited as Cover work)

6.M. Tian, Lei Shen*, Self-coiling of single-stranded protofibrils into rings: A pathway of Alzheimer’s beta-peptide amyloidosis on lipid membranes. ACS Macro Lett. 2020, 9, 813. (Invited as Cover work)

7.J. Liu, M. Tian, Lei Shen*, Surface effects on the degree of twist in amyloid fibril structures. Chem. Commun. 2020, 56, 3147.

8.J. Liu, M. Tian, Lei Shen*, Nanopatterned polymer surface modulates twist polymorphism in a single amyloid fibril. Macro. Rapid Commun. 2020, 41, 1900619.

9.S. Cai, J. Liu, M. Tian, K Wang, Lei Shen*, Diffusion dynamics of a single collapsed homopolymer globule at solid-liquid interface. Soft Matter, 2020, 16, 2431. (Invited as Cover work)

10.S. Gong, J. Liu, M. Tian, K Wang, S. Cai, W. Wang, Lei Shen*, Unravelling the mechanism of amyloid-β peptide oligomerization and fibrillation at chiral interfaces. Chem. Commun., 2019, 55, 13725.

11.P. Li, Y. Shen, L. Wang, W. Lu, W. Li, K. Chen, Y. Zhou, Lei Shen*, F. Wei*, W. Zheng, The electric double layer structure modulates poly-dT25 conformation and adsorption kinetics at the cationic lipid bilayer interface. Soft Matter, 2019, 15, 4445. (Invited as Cover work)

12.J. Lin, K. Wang, X. Xia, Lei Shen*. Quantification of Multivalency in Protein Oligomer Coated Nanoparticles Targeting Dynamic Membrane Glycan Receptors. Langmuir, 2018, 34, 8415.

13.M. Yang, K. Wang, J. Lin, L. Wang, F. Wei*, J. Zhu, W. Zheng, Lei Shen*. Gel phase membrane retards amyloid beta-peptide (1-42) fibrillation by restricting slaved diffusion of peptides on lipid bilayers. Langmuir, 2018, 34, 8408.

14.K. Shezad, K. Zhang, M. Hussain, H. Dong, C. He, X. Gong, X. Xie, J. Zhu*, Lei Shen*. Surface roughness modulated diffusion and fibrillation of amyloid-beta peptide. Langmuir, 2016, 32, 8238.

15.Lei Shen, Y. Wang, C. Lin, H. Liu*, A. Guo*, X. Y. Zhu*. Membrane environment can enhance the interaction of glycan binding protein to cell surface glycan receptors. ACS Chem. Biol., 2014, 9, 1877.

16.Lei Shen, T. Adachi, D. Vanden Bout, X. Y. Zhu*. A mobile precursor determines amyloid-beta peptide fibril formation at interfaces. J. Am. Chem. Soc., 2012, 134, 14172.

招生方向:

物理化学、材料、高分子等。

欢迎喜欢大分子材料的你加入课题组!

近年来培养的研究生获国家及校一等奖学金、三好学生和优秀毕业生称号,本科生多次获国家省级竞赛一、二等奖。

Prof. Lei Shen

Email: leishen@whut.edu.cn

Education

2003   B.Sc.  University of Science & Technology of China

2008   Ph.D.  University of Science & Technology of China

Position

Since 2017    Professor, Wuhan University of Technology

2014-2016    Associate Professor, Huazhong University of Science and Technology

2012-2013    Associate Research Scientist, Columbia University, USA

2009-2012    Research Associate, The University of Texas at Austin, USA

2009-2009    Research Associate, University of Minnesota, USA

2008-2009    Research Associate, University of Geneva, Switzerland

Research Interests

Our research interests focus on soft matter, such as macromolecules at surfaces, bio-interface phenomena and biomaterials, including:

1.nucleation and fiber formation of neuro-degenerative diseases related proteins and peptides;

2.molecular characteristic properties of polymers at surfaces;

3.molecular dynamics simulations of macromolecular systems;

4.design, synthesis and modification of functional soft biomaterials, such as artificial blood vessels, medical devices and drug systems.

Representative Publications

1.Guanbin Gao*, Xinglin Liu, Zhenhua Gu, Qingxue Mu, Guowei Zhu, Ting Zhang, Cheng Zhang, Lin Zhou, Lei Shen*, Taolei Sun*. Engineering Nanointerfaces of Au25-Clusters for Chaperone-Mediated Peptide Amyloidosis. Nano Lett. 2022 .

2.L. Wen, Lei Shen*. Effect of Surface-Chelated Cu2+ on Amyloid-β Peptide Fibrillation. Langmuir, 2022, 38, 174.

3.Y. Song, Y. Geng, Lei Shen*. Visualizing Super-Diffusion, Oligomerization and Fibrillation of Amyloid-β Peptide Chains along Tubular Membranes ACS Macro Lett. 2021, 10, 1295. (Invited as Cover work)

4.X. Zhou, M. Zhao, Y. Y. Liu, Q. J. Chen, Lei Shen*. Statistical Binding Matching Between Influenza-A-Virus and Dynamic Glycan Clusters Determines Its Adhesion onto Lipid Membranes. Langmuir, 2020, 36, 15212. (Invited as Cover work)

5.M. Tian, B. Li*, Lei Shen*. Hierarchical Self-Assembly Mechanism of Ladder-Like Orientated Aβ40 Single-Stranded Protofibrils into Multistranded Mature Fibrils. ACS Macro Lett. 2020, 9, 1759. (Invited as Cover work)

6.M. Tian, Lei Shen*, Self-coiling of single-stranded protofibrils into rings: A pathway of Alzheimer’s beta-peptide amyloidosis on lipid membranes. ACS Macro Lett. 2020, 9, 813. (Invited as Cover work)

7.J. Liu, M. Tian, Lei Shen*, Surface effects on the degree of twist in amyloid fibril structures. Chem. Commun. 2020, 56, 3147.

8.J. Liu, M. Tian, Lei Shen*, Nanopatterned polymer surface modulates twist polymorphism in a single amyloid fibril. Macro. Rapid Commun. 2020, 41, 1900619.

9.S. Cai, J. Liu, M. Tian, K Wang, Lei Shen*, Diffusion dynamics of a single collapsed homopolymer globule at solid-liquid interface. Soft Matter, 2020, 16, 2431. (Invited as Cover work)

10.S. Gong, J. Liu, M. Tian, K Wang, S. Cai, W. Wang, Lei Shen*, Unravelling the mechanism of amyloid-β peptide oligomerization and fibrillation at chiral interfaces. Chem. Commun., 2019, 55, 13725.

11.P. Li, Y. Shen, L. Wang, W. Lu, W. Li, K. Chen, Y. Zhou, Lei Shen*, F. Wei*, W. Zheng, The electric double layer structure modulates poly-dT25 conformation and adsorption kinetics at the cationic lipid bilayer interface. Soft Matter, 2019, 15, 4445. (Invited as Cover work)

12.J. Lin, K. Wang, X. Xia, Lei Shen*. Quantification of Multivalency in Protein Oligomer Coated Nanoparticles Targeting Dynamic Membrane Glycan Receptors. Langmuir, 2018, 34, 8415.

13.M. Yang, K. Wang, J. Lin, L. Wang, F. Wei*, J. Zhu, W. Zheng, Lei Shen*. Gel phase membrane retards amyloid beta-peptide (1-42) fibrillation by restricting slaved diffusion of peptides on lipid bilayers. Langmuir, 2018, 34, 8408.

14.K. Shezad, K. Zhang, M. Hussain, H. Dong, C. He, X. Gong, X. Xie, J. Zhu*, Lei Shen*. Surface roughness modulated diffusion and fibrillation of amyloid-beta peptide. Langmuir, 2016, 32, 8238.

15.Lei Shen, Y. Wang, C. Lin, H. Liu*, A. Guo*, X. Y. Zhu*. Membrane environment can enhance the interaction of glycan binding protein to cell surface glycan receptors. ACS Chem. Biol., 2014, 9, 1877.

16.Lei Shen, T. Adachi, D. Vanden Bout, X. Y. Zhu*. A mobile precursor determines amyloid-beta peptide fibril formation at interfaces. J. Am. Chem. Soc., 2012, 134, 14172.


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