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沈雷

发布时间：2019.01.16 14:49


沈雷  男  理学博士  教授 硕/博士生导师

Email：leishen@whut.edu.cn


教育经历：

1999-2003，中国科学技术大学，化学物理专业，本科

2003-2008，中国科学技术大学&加拿大多伦多大学，博士(联培)，导师：吴奇院士&Prof. Mitchell A. Winnik


工作经历：

2008-2009，瑞士日内瓦大学，博士后，合作导师：Michal Borkovec教授

2009-2012，美国德州大学&明尼苏达大学，博士后，合作导师：Xiaoyang Zhu教授&Timothy Lodge教授

2012-2013，美国哥伦比亚大学，化学系，助理研究员

2013-2016，华中科技大学，化学与化工学院，副教授

2017-现在，武汉理工大学，化学化工与生命科学学院，教授，副院长


研究方向：

大分子表界面物理化学：聚焦大分子表界面科学，瞄准生命健康，融合科学实验与计算模拟，揭示表界面上大分子链行为及其相互作用微观机制，从物理机制源头创制生物医药材料，如神经退行性疾病药物、人工小血管(直径<4mm)、缝合器械等。


课程教学：

科教深度融合：通过“知识-能力-素质”一体化育人，培养本科生和研究生基础创新能力。

讲授物理化学、高分子化学及物理等课程。在北大核心期刊发表教研论文多篇。指导的研究生获国家级一等奖学金、校三好学生和优秀毕业生等称号，本科生多次获国家级省级以及校级竞赛一、二等奖。


科研项目及获得荣誉：

  1. 国家自然科学基金联合基金重点项目，2026-2030；

  2. 国家自然科学基金面上项目，2022-2025；

  3. 国家自然科学基金面上项目，2015-2019；

  4. 国家自然科学基金青年项目，2014-2016；

  5. 武汉理工大学"15551"青年拔尖人才计划，2019-2024；

  6. 湖北省人才计划，2015，高分子化学与物理；

  7. 武汉理工大学第十届青年教师教学竞赛，2020，二等奖；

  8. 武汉理工大学第二届教师教学创新大赛，2022，特等奖。


申报国家发明专利：

      1. 一种抑制β-淀粉样蛋白纤维化的磷脂化合物及其制备方法，中国专利，202510485239.0，

      2. 一种人工血管材料及利用其制备的无涂层式一体化抗凝血小口径人工血管，中国专利，202211281212.2，

      3. 一种吻合器，中国专利，202222743945.5，2023

      4. 一种高效抗菌促愈合纳米纤维伤口敷料的制备及其应用，中国专利，2022

      5. 一种多糖微凝胶的制备方法，中国专利，201510326329.1，2015

      6. Loading quantum dots into thermo-responsive microgels by reversible transfer from organic solvents to water. 美国专利，US7914710 B2，2011


近期代表性论文：

在国际核心期刊上发表学术论文70余篇，包括PNAS、JACS、Macromolecules、ACS Macro Lett.等，他引3000余次，多篇被选为封面或亮点评论。多次被审稿人和国际同行亮点评述，在国际权威胶体界面化学综述期刊Adv. Colloid Interface Sci.和国内高分子核心刊物《高分子学报》撰写综述评论文章。


  1. C. Cheng, Y. Zeng, Guanbin Gao*, Taolei Sun*, Lei Shen*. Flexibility Analysis of DNA Nanotubes with Prescribed Circumferences and Their Pearl-necklace Assemblies with Gold Nanoclusters. Langmuir,2023.

  2. Y. Geng, T. Huang, W. Zhou, Lei Shen*. Physical Mechanism of Amyloid-β Peptide Chain Aggregation on Fluidic Lipid Nanotubules. Langmuir,2022.

  3. Guanbin Gao*, X. Liu, Z. Gu, Q. Mu, G. Zhu, T. Zhang, C. Zhang, L. Zhou, Lei Shen*, Taolei Sun*.Engineering Nanointerfaces of Au25-Clusters for Chaperone-Mediated Peptide Amyloidosis. Nano Lett. 2022,22, 2964.

  4. L. Wen, Lei Shen*. Effect of Surface-Chelated Cu2+on Amyloid-β Peptide Fibrillation. Langmuir,2022,38, 174.

  5. Y. Song, Y. Geng, Lei Shen*. Visualizing Super-Diffusion, Oligomerization and Fibrillation of Amyloid-β Peptide Chains along Tubular Membranes ACS Macro Lett. 2021,10, 1295. (Invited as Cover work)

  6. X. Zhou, M. Zhao, Y. Y. Liu, Q. J. Chen, Lei Shen*. Statistical Binding Matching Between Influenza-A-Virus and Dynamic Glycan Clusters Determines Its Adhesion onto Lipid Membranes. Langmuir,2020,36, 15212. (Invited as Cover work)

  7. M. Tian, B. Li*, Lei Shen*. Hierarchical Self-Assembly Mechanism of Ladder-Like Orientated Aβ40 Single-Stranded Protofibrils into Multistranded Mature Fibrils. ACS Macro Lett. 2020, 9, 1759. (Invited as Cover work)

  8. M. Tian, Lei Shen*, Self-coiling of single-stranded protofibrils into rings: A pathway of Alzheimer’s beta-peptide amyloidosis on lipid membranes. ACS Macro Lett. 2020, 9, 813. (Invited as Cover work)

  9. J. Liu, M. Tian, Lei Shen*, Surface effects on the degree of twist in amyloid fibril structures. Chem. Commun. 2020, 56, 3147.

  10. S. Cai, J. Liu, M. Tian, K Wang, Lei Shen*, Diffusion dynamics of a single collapsed homopolymer globule at solid-liquid interface.Soft Matter,2020, 16, 2431. (Invited as Cover work)

  11. S. Gong, J. Liu, M. Tian, K Wang, S. Cai, W. Wang, Lei Shen*, Unravelling the mechanism of amyloid-β peptide oligomerization and fibrillation at chiral interfaces. Chem. Commun., 2019, 55, 13725.

  12. P. Li, Y. Shen, L. Wang, W. Lu, W. Li, K. Chen, Y. Zhou, Lei Shen*, F. Wei*, W. Zheng, The electric double layer structure modulates poly-dT25 conformation and adsorption kinetics at the cationic lipid bilayer interface.Soft Matter,2019, 15, 4445. (Invited as Cover work)

  13. J. Lin, K. Wang, X. Xia, Lei Shen*. Quantification of Multivalency in Protein Oligomer Coated Nanoparticles Targeting Dynamic Membrane Glycan Receptors. Langmuir,2018, 34, 8415.

  14. M. Yang, K. Wang, J. Lin, L. Wang, F. Wei*, J. Zhu, W. Zheng, Lei Shen*. Gel phase membrane retards amyloid beta-peptide (1-42) fibrillation by restricting slaved diffusion of peptides on lipid bilayers. Langmuir,2018, 34, 8408.


招生方向：

物理化学、材料、高分子等。

欢迎喜欢大分子材料的你加入课题组！

近年来培养的研究生获国家及校一等奖学金、三好学生和优秀毕业生称号，本科生多次获国家省级竞赛一、二等奖。


Prof. Lei Shen

Email:leishen@whut.edu.cn


Education

2003   B.Sc.  University of Science & Technology of China

2008   Ph.D.  University of Science & Technology of China


Position

Since 2017    Professor, Wuhan University of Technology

2014-2016    Associate Professor, Huazhong University of Science and Technology

2012-2013    Associate Research Scientist, Columbia University, USA

2009-2012    Research Associate, The University of Texas at Austin, USA

2009-2009    Research Associate, University of Minnesota, USA

2008-2009    Research Associate, University of Geneva, Switzerland


Research Interests

Our research interests focus on bio-interface, such as macromolecule dynamics at biomembranes and surfaces, and create biomedical materials from the source of physical mechanisms:

  1. nucleation and fiber formation of neuro-degenerative diseases related proteins and peptides;

  2. molecular characteristic properties of biopolymers at surfaces;

  3. molecular dynamics simulations of macromolecular systems;

  4. design, synthesis and modification of functional soft biomaterials, such as artificial blood vessels, medical devices and drug systems.


Representative Publications

      1. C. Cheng, Y. Zeng, Guanbin Gao*, Taolei Sun*, Lei Shen*. Flexibility Analysis of DNA Nanotubes with Prescribed Circumferences and Their Pearl-necklace Assemblies with Gold Nanoclusters. Langmuir,2023.

      2. Y. Geng, T. Huang, W. Zhou, Lei Shen*. Physical Mechanism of Amyloid-β Peptide Chain Aggregation on Fluidic Lipid Nanotubules. Langmuir,2022.

      3. Guanbin Gao*, X. Liu, Z. Gu, Q. Mu, G. Zhu, T. Zhang, C. Zhang, L. Zhou,Lei Shen*, Taolei Sun*.Engineering Nanointerfaces of Au25-Clusters for Chaperone-Mediated Peptide Amyloidosis. Nano Lett. 2022,22, 2964.

      4. L. Wen, Lei Shen*. Effect of Surface-Chelated Cu2+on Amyloid-β Peptide Fibrillation. Langmuir,2022,38, 174.

      5. Y. Song, Y. Geng, Lei Shen*. Visualizing Super-Diffusion, Oligomerization and Fibrillation of Amyloid-β Peptide Chains along Tubular Membranes ACS Macro Lett. 2021,10, 1295. (Invited as Cover work)

      6. X. Zhou, M. Zhao, Y. Y. Liu, Q. J. Chen, Lei Shen*. Statistical Binding Matching Between Influenza-A-Virus and Dynamic Glycan Clusters Determines Its Adhesion onto Lipid Membranes. Langmuir,2020,36, 15212. (Invited as Cover work)

      7. M. Tian, B. Li*, Lei Shen*. Hierarchical Self-Assembly Mechanism of Ladder-Like Orientated Aβ40 Single-Stranded Protofibrils into Multistranded Mature Fibrils. ACS Macro Lett.2020, 9, 1759. (Invited as Cover work)

      8. M. Tian, Lei Shen*, Self-coiling of single-stranded protofibrils into rings: A pathway of Alzheimer’s beta-peptide amyloidosis on lipid membranes. ACS Macro Lett. 2020, 9, 813. (Invited as Cover work)

      9. J. Liu, M. Tian, Lei Shen*, Surface effects on the degree of twist in amyloid fibril structures. Chem. Commun. 2020, 56, 3147.

      10. S. Cai, J. Liu, M. Tian, K Wang, Lei Shen*, Diffusion dynamics of a single collapsed homopolymer globule at solid-liquid interface. Soft Matter, 2020, 16, 2431. (Invited as Cover work)

      11. S. Gong, J. Liu, M. Tian, K Wang, S. Cai, W. Wang, Lei Shen*, Unravelling the mechanism of amyloid-β peptide oligomerization and fibrillation at chiral interfaces. Chem. Commun., 2019, 55, 13725.

      12. P. Li, Y. Shen, L. Wang, W. Lu, W. Li, K. Chen, Y. Zhou, Lei Shen*, F. Wei*, W. Zheng, The electric double layer structure modulates poly-dT25 conformation and adsorption kinetics at the cationic lipid bilayer interface. Soft Matter, 2019, 15, 4445. (Invited as Cover work)

      13. J. Lin, K. Wang, X. Xia, Lei Shen*. Quantification of Multivalency in Protein Oligomer Coated Nanoparticles Targeting Dynamic Membrane Glycan Receptors. Langmuir,2018, 34, 8415.

      14. M. Yang, K. Wang, J. Lin, L. Wang, F. Wei*, J. Zhu, W. Zheng, Lei Shen*. Gel phase membrane retards amyloid beta-peptide (1-42) fibrillation by restricting slaved diffusion of peptides on lipid bilayers.Langmuir,2018, 34, 8408.


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