吴建平

发布时间:2019.03.11 08:44


姓名:吴建平

性别:

出生年月:196811

学位:博士

职称:教授

联系电话:18062552085   

Emailbiojpwu@whut.edu.cn or biojpwu@gmail.com

教育经历:

1994/09 – 1997/07 武汉同济医科大学,预防医学,博士

1991/09 – 1994/07 武汉同济医科大学,预防医学,硕士

1986/09 – 1991/07 武汉同济医科大学,环境医学,学士

研究经历:

2018.03~至今武汉理工大学,化学化工与生命科学学院,教授

2012.03~2018.03 Virginia Tech Carilion School of Medicine, Assistant Professor

2009.10~2012.03 Washington University in St. Louis, Sr. Scientist

2003.07~2009.10 University of Alabama at Birmingham, Research Associate

1999.07~2003.07 Georgia State University, Post-Doc Research Associate 

科研概况:

主要从事离子通道、受体及转运蛋白结构与功能的基础研究,在KCNT钾通道、Na+/HCO3-共转运体(NBC)结构功能调控、药物筛选等相关领域进行了系统而深入的研究,取得了若干创新性研究成果。2009建立NBC巨片钳测定方法,在国际上首次观察到PIP2信号途径对NBC活性调控存在不同作用模式(PNAS2009)。近年来研究兴趣侧重于离子通道、受体在脑血管病、癫痫等重要神经系统疾病的发病机制中作用及临床干预对策研究。

研究领域:

1)脑血管病:侧重于脑功能保护基础研究及药物研发

2)中枢神经网络的代谢性调控与癫痫:难治性癫痫发病机制、抗癫痫药物筛选

主要科研项目:

1)ITPKA/IP4PI3K/AKT信号途径交互调控NBCs活性引发脑缺血再灌注迟发性神经元死亡机制研究,主持, 国家自然科学基金(81870935) 20192022

2)神经药理基础与创新,主持,武汉理工大学,2018年~2023

专业协会及学术兼职:

1999~至今:Society for Neurosciences(SFN), Member

2003~至今:American Epilepsy Society(AES), Active Member

2019~至今:中国卒中学会转化医学分会,委员;

2019~至今:中国医师协会神经修复学专业委员会,委员;

2021~至今:中国抗癫痫学会药物治疗专业委员会,委员;

2022~2025CNS & Neurological Disorders-Drug TargetsSection Editor;           Frontiers in Behavioral Neuroscience, Review Editor

代表性论文与专利:

For a more complete list of publications, visit the following PubMed site htwww.ncbi.nlm.nih.gov/myncbi/jianping.wu.1/bibliography/public/

1)Zahra A#, Liu R#, Han WZ, Meng H, Wang YF, Wang Q, Campbell SL, Wu J. KCa-linked Channelopathies: Phenotypic spectrum and Therapeutic indications KCNT channel. Curr Neuropharmacol. 2022 (in press). 

2)Wang JJ#, Zahra A#, Wang YF, Wu J. Understanding the physiological role of electroneutral Na+-coupled HCO3− cotransporter and its therapeutic implications. Pharmaceuticals (Basel). 2022,15, 1082. doi.org/10.3390/ph15091082.

3)Zhang Q, Jia M, Zahra A, Wang YF, Wang Q, Campbell SL, Wu J. Cell death in cerebral ischemia-reperfusion injury. Neurochem Res. 2022 Aug 17. doi: 10.1007/s11064-022-03697-8. Epub ahead of print. PMID: 35976487.

4)Xia H, Zahra A, Jia M, Wang Q, Wang YF Campbell SL, Wu J. Na+/H+ exchanger 1, a potential therapeutic drug target for cardiac hypertrophy and heart failure. Pharmaceuticals (Basel). 2022 Jul 15;15(7). doi: 10.3390/ph15070875.

5)Jia M#, Zhang Q#, Guo X, Liu R, Liu S, Chen N, Wang YF, Wang Q, Campbell SL, Wu J. Na+/HCO3- Co-transporters Inhibitor S0859 Attenuates Global Cerebral Ischemia-reperfusion Injury of the CA1 Neurons in the Gerbil's Hippocampus.CNS Neurol Disord Drug Targets. 2022 May 17; doi: 10.2174/1871527321666220517121135. 

6)Zahra A, Wang Y, Wang Q, Wu J.Shared Etiology in Autism Spectrum Disorder and Epilepsy with Functional Disability.Behav Neurol. 2022; 2022:5893519. doi: 10.1155/2022/5893519.

7)Zahra A, Du L, Jia M, Butt MU, Wang Q, Wang Y, Wu J.Prenatal exposure of citalopram elicits depression-like and anxiety-like behaviors and alteration of morphology and protein expression of medial prefrontal cortex in young adult mice.J Integr Neurosci.2022 Mar 23;21(2):61. doi: 10.31083/j.jin2102061.

8)Sun L#, Liu R#, Yang H, Yu T, Wu J*, Wang Q*.Characteristics of Epileptiform Spike-wave Discharges and Chronic Histopathology in Controlled Cortical Impact Model of Sprague-Dawley Rats.Neurochem Res. 2022 Feb 1;. doi: 10.1007/s11064-022-03542-y.

9)Liu R, Sun L, Wang Y, Jia M, Wang Q, Cai X*, Wu J*.Double-edged Role of KNaChannels in Brain Tuning: Identifying Epileptogenic Network Micro-Macro Disconnection.Curr Neuropharmacol. 2022;20(5):916-928. doi: 10.2174/1570159X19666211215104829.

10)Du L, Zahra A, Jia M, Wang Q, Wu J.Understanding the Functional Expression of Na+-Coupled SLC4 Transporters in the Renal and Nervous Systems: A Review.Brain Sci. 2021 Sep 26;11(10). doi: 10.3390/brainsci11101276. 

11)Sun L, Shan W, Yang H, Liu R, Wu J*, Wang Q*.The Role of Neuroinflammation in Post-traumatic Epilepsy.Front Neurol. 2021;12:646152. doi: 10.3389/fneur.2021.646152. 

12)Lu M, Jia M, Wang Q, Guo Y, Li C, Ren B,* Qian F*, Wu J*.The electrogenic sodium bicarbonate cotransporter and its roles in the myocardial ischemia-reperfusion induced cardiac diseases.Life Sci. 2021 Apr 1;270:119153. doi: 10.1016/j.lfs.2021.119153.

13)Kong Z, Wang Y, Zhang Y, Shan W, Wu J, Wang Q.MicroRNA-126 promotes endothelial progenitor cell proliferation and migration ability via the Notch pathway.Cardiovasc Diagn Ther. 2020 Jun;10(3):490-499. doi: 10.21037/cdt-20-178. 

14)Yang H, Shan W, Zhu F, Wu J, Wang Q.Ketone Bodies in Neurological Diseases: Focus on Neuroprotection and Underlying Mechanisms.Front Neurol. 2019;10:585. doi: 10.3389/fneur.2019.00585. 

15)Zhu F, Shan W, Xu Q, Guo A, Wu J, Wang Q.Ketone Bodies Inhibit the Opening of Acid-Sensing Ion Channels (ASICs) in Rat Hippocampal Excitatory Neuronsin vitro.Front Neurol. 2019;10:155. doi: 10.3389/fneur.2019.00155.

16)Martinez-Espinosa PL#, Wu J#, Yang C, Gonzalez-Perez V, Zhou H, Liang H, Xia XM, Lingle CJ.Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons.Elife. 2015 Nov 11;4. doi: 10.7554/eLife.10013. 

17)Thornell IM, Wu J, Liu X, Bevensee MO.PIP2 hydrolysis stimulates the electrogenic Na+-bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus laevis oocytes.J Physiol. 2012 Dec 1;590(23):5993-6011. doi: 10.1113/jphysiol.2012.242479.

18)Wang W, Wu J, Bernard K, Li G, Wang G, Bevensee MO, Kirk KL.ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.Proc Natl Acad Sci USA. 2010 Feb 23;107(8):3888-93. doi: 10.1073/pnas.0913001107. 

19)Wu J, McNicholas CM, Bevensee MO.Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/HCO3 cotransporter NBCe1-A expressed in Xenopus oocytes.Proc Natl Acad Sci USA. 2009 Aug 18;106(33):14150-5. doi: 10.1073/pnas.0906303106. 

20)Rojas A, Wu J, Wang R, Jiang C.Gating of the ATP-sensitive K+ channel by a pore-lining phenylalanine residue.Biochim Biophys Acta. 2007 Jan;1768(1):39-51. doi: 10.1016/j.bbamem.2006.06.027.

21)Wu J, Hablitz JJ.Cooperative activation of D1 and D2 dopamine receptors enhances a hyperpolarization-activated inward current in layer I interneurons.J Neurosci. 2005 Jul 6;25(27):6322-8. doi: 10.1523/JNEUROSCI.1405-05.2005. 

22)Wu J, Xu H, Shen W, Jiang C.Expression and coexpression of CO2-sensitive Kir channels in brainstem neurons of rats.J Membr Biol. 2004 Feb 1;197(3):179-91. doi: 10.1007/s00232-004-0652-4.

23)Wu J, Piao H, Rojas A, Wang R, Wang Y, Cui N, Shi Y, Chen F, Jiang C.Critical protein domains and amino acid residues for gating the KIR6.2 channel by intracellular ATP.J Cell Physiol. 2004 Jan;198(1):73-81. doi: 10.1002/jcp.10388. 

24)Wang X, Wu J, Li L, Chen F, Wang R, Jiang C.Hypercapnic acidosis activates KATP channels in vascular smooth muscles.Circ Res. 2003 Jun 13;92(11):1225-32. doi: 10.1161/01.RES.0000075601.95738.6D.

25)Wu J, Xu H, Yang Z, Wang Y, Mao J, Jiang C.Protons activate homomeric Kir6.2 channels by selective suppression of the long and intermediate closures.J Membr Biol. 2002 Nov 15;190(2):105-16. doi: 10.1007/s00232-002-1029-1. 

26)Wu J, Cui N, Piao H, Wang Y, Xu H, Mao J, Jiang C.Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP.J Physiol. 2002 Sep 1;543(Pt 2):495-504. doi: 10.1113/jphysiol.2002.025247.

大会报告

1)吴建平中枢KCNT钾通道功能与外伤后难治性癫痫中国卒中学会第五届学术年会暨天坛国际脑血管病会议(专题报告)。 北京国家会议中心, 2019.6.28

2)吴建平 基于NBC抑制的神经保护剂研发与临床应用。中国卒中学会神经修复分会第二届学术年会(专题报告)。 重庆国际会议中心, 2021.5.20

会议墙报、摘要

3)Du L, Zahra A, Wang Q, Wang YF, Wu J. Prenatal Citalopram exposure induced anxiety and depression-like behavior with medial prefrontal cortex dysfunction during adolescence. SFN Meeting, 2021, Chicago

4)Jia M, Chan W, Wang YJ, W Q and Wu J. Inhibition of NBCs activity protects hippocampus CA1 delayed neuronal death induced by transient global cerebral ischemia in gerbils. SFN Meeting, 2019, Chicago

5)Wu J and Friedlander MJ. Regular and irregular (Poisson) conditioning trains induced synaptic plasticity between individual neurons in layer 4 of mouse visual cortex. Abstract for SFN, 2016, San Diego

6)Wu J and Friedlander MJ. Effects of irregular (Poisson) conditioning trains on synaptic plasticity between individual neurons in layer 4 of mouse visual cortex, Abstract for SFN, 2015, Chicago

7)Wu J and Friedlander MJ. Regular and irregular (Poisson) conditioning trains induced synaptic plasticity between individual neurons in layer 4 of mouse visual cortex. Abstract for SFN, 2016, San Diego

8)Wu J and Tyler WJ.  Mechanical bioeffects of pulsed ultrasound  modulate the activity of TREK-1 potassium channels, Abstract for SFN, 2013, San Diego, CA

9)Wu J, Liu XF, Thornell IM and Bevensee MO. Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulation of electrogenic Na/bicarbonate cotransporter NBCe1 variants expressed in Xenopus laevis oocytes FASEB J April 22, 2009 23:800.13

10)Wu J, McNicholas-Bevensee CM, Bevensee MO. Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/bicarbonate cotransporter NBCe1-A. FASEB. J April 18, 2007 21:A1285 (Abstract for  EB meeting, 2007, DC)

11)Wu J, Hablitz JJ. Tonic GABAB inhibition regulates neurotransmission in prefrontal cortex.  Abstracts for SFN.2005.

12)Wu J, Hablitz JJ. Dopamine-GABAB Interaction in Modulation of EPSCs in Layer I Interneurons.  Abstracts for SFN.2004.

13)Wu J, Rojas A, Wang R and Chun Jiang. Gating of the Kir6.2 channel may involve spatial hindrance effct by Phe168 at the intracellular end of the M2 helix bundle-crossing. Abstracts of SFN.2003.

14)Wu J, Piao H, Cui N, Jiang C. Both M1 and M2 domains are required for Gating KATP channel by intracellular ATP. Abstract for Biophysics Meeting 2003, 393-pos

15)Wu J., Xu H., Mao J; C. Jiang. Gating of KATP channel by intercellular proton and ATP. Abstracts of SFN.27: 708.19,2001.

16)Wu J., Xu H. W. Shen; C. Jiang. Colocalization of Kir4.1 and Kir5.1 mRNA in brainstem neurons. Abstracts of SFN. 26: 154.8, 2000.

学术奖励及荣誉:

National Alliance for Research on Schizophrenia and Depression”  Young Investigator Award (NARSD, 2006)




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