雷志鑫

发布时间:2021.04.15 15:28
  姓名:雷志鑫
  性别:男
  出生年月:1991.01
  民族:汉
  学历:博士
  职称:研究员
  电话:+86-17786505091
  电子邮箱:leizhixin@whut.edu.cn
 
  教育背景
  2018:明尼苏达大学,药学院,药剂系,访问学者
  2013-2018 : 华中农业大学,基础兽医系,兽医药理与毒理学,博士
  2008-2013 :华中农业大学,动物医学,学士
  工作经历
  2018-2020 明尼苏达大学,医学院,神经科学系,博士后
  2021/02至今 | 武汉理工大学,化生学院,制药工程系,研究员
  科研工作
  研究领域
  药理(针对细菌与病毒药物的药动、药代、耐药性、耐药机制、药物评价等研究)
  药剂(针对企业,药物新剂型研制如PLGA、SLN、靶向抗菌肽等)
  毒理(遗传毒性、致癌机制)
  神经免疫(信号通路、多发性硬化症病理机制)
  代表性论文 
  1. Zhixin Lei, et al. NF-κB activation accounts for the cytoprotective effects of PERK activation on oligodendrocytes during EAE. Journal of Neuroscience, 40(33): 6444-6456. doi: 10.1523/JNEUROSCI.1156-20.2020. 
  2. Zhixin Lei, et al. Comparative transcriptional profiling of tildipirosin-resistant and sensitive Haemophilus parasuis. Scientific Reports. 7(1):7517, (2017). 
  3. Zhixin Lei, et al. Optimal Regimens and Cut-off Evaluation of Tildipirosin against Pasteurella Multocida. Frontiers in Pharmacology, doi: 10.3389/fphar.2018.00765, (2018).
  4. Zhixin Lei, et al. Evaluation of Marbofloxacin in beagle dogs after oral dosing: Preclinical safety evaluation and comparative pharmacokinetics of two different tablets. Frontiers in pharmacology. doi: 10.3389/fphar.2018.00306, (2018). 
  5. Zhixin Lei#, et al. Comparative pharmacokinetics and preliminary pharmacodynamics evaluation of Piscidin 1 against PRV and PEDV in rats. Frontiers in Chemistry, doi:10.3389/fchem.2018.00244, (2018). SCI, (IF:4.7, 2区)
  6. Zhixin Lei, et al. Resistant cutoff values and optimal scheme establishments for florfenicol against Escherichia coli with PK-PD modeling analysis in pigs. J Vet Pharmacol Ther. 2019 May;42(3):324-335. doi: 10.1111/jvp.12754. 
  7. Zhixin Lei#, et al. N-O reduction and ROS-mediated AKT/FOXO1 and AKT/P53 pathways were involved in growth promotion and cytotoxicity of Cyadox. Chem Res Toxicol. doi: 10.1021/acs.chemrestox.8b00194, (2018). 
  8. Zhixin Lei#, et al. Mequindox induces apoptosis, DNA damage, and carcinogenicity in Wistar rats. Food Chem Toxicol. 2019 May;127:270-279. doi: 10.1016/j.fct.2019.03.025. 
  科研项目
  (1) 武汉理工大学人才引进科研启动项目,2021年-至今,主持
  (2)武汉理工大学校自主创新基金, 2021.4-2022.10,主持
  
写给学生的话
  如果你有梦想,我愿为你的梦想插上翅膀!
 

 

  

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