研究员、博士/硕士导师

基本情况

出生年月：1989.01

最高学位：哥本哈根大学博士

工作单位：深圳华大生命科学研究院

工作地址：广东深圳市盐田区云华路9号华大时空中心

Email:zouyuanqiang@genomics.cn

教育及工作经历

2010.07– 至今     深圳华大生命科学研究院，研究员

2018.12– 2023.10   哥本哈根大学，分子生物医学专业，哲学博士

2013.09 – 2015.12   华南理工大学，生物工程专业，工学硕士

2006.09 – 2010.06     西北农林科技大学，生物科学专业，本科

学术兼职

研究领域及主要成果

研究领域：人体微生物培养组、基因组；人体微生物与宿主互作；微生物功能研究与转化。

主要成果：构建了迄今为止该领域最大的肠道菌株库和肠道参考基因组数据库，相关成果被评选为《2019年度中国生物信息学十大应用》和《2019年度中国生物信息学十大进展》。在国际顶级期刊《Nature biotechnology》，《Nature genetics》，《Nature Communications》，《iMeta》等国际期刊发表论文或评论60篇，申请专利30余项。主导多项益生菌的知识产权的产业转化，收益3000余万。主持并参与国自然、深圳市科技项目10余项。参与2项团队标准的制定。

主持科研项目

“胆汁酸介导的克里斯坦森氏菌对非酒精性脂肪肝的作用机理研究”——国自然面上项目，32570057，2026/01-2029/12、50万元、主持。

“基于比较基因组学探究人体肠道可培养优势菌Faecalibacterium prausnitzii的遗传多样性”——国自然青年基金，32100009，2022/01-2024/12、30万元、主持。

获奖情况

代表性论文、专著和专利等（不超过10项）

代表性论文：

1. Zhuye Jie, Hewei Liang, Yanzheng Meng, Jiahao Zhang, Tao Zhang, Wenxi Li, Xiaoqian Lin, Tongyuan Hu, Mo Han, Weiting Liang, Yanmei Ju, Xin Tong, Xin Jin, Xun Xu, Wenwei Zhang, Jian Wang, Huanming Yang, Karsten Kristiansen, Liang Xiao* & Yuanqiang Zou*. Integrating metagenomics and cultivation unveils oral phage diversity and potential impact on hosts. npj biofilms and microbiomes. 2025 11, 145.

1. Cong Yang, Jingxi Sun, Ling Li, Jin Zheng, Chuhan Wang, Yu Zhao, Duo Yun, , Zhinan Wu, Hewei Liang, Wenxi Li, Tongyuan Hu, Rui Guo, Liang Xiao, Yuanqiang Zou*, Zhigang Liu*. Synbiotics of Lactobacillus suilingensisand inulin alleviates cognitive impairment via regulating gut microbiota indole-3-lactic acid metabolism in female AD mice.Alzheimer's & Dementia. 2025 21, 7.

1. Wenxin He, Hewei Liang, Wenxi Li, Xiaowei Gao, Tongyuan Hu, Xiaoqian Lin, Zhinan Wu, Jingxi Sun, Xiaofang Li, Mengmeng Wang, Xiaoxue Hou, Zhuye Jie, Xin Tong, Xin Jin, Liang Xiao & Yuanqiang Zou*.Revealing an unprecedented diversity of episymbiotic Saccharibacteria in a high-quality genome collection.npj biofilms and microbiomes. 2024. 10, 153.

2. Xiaoqian Lin, Tongyuan Hu, Zhinan Wu, Lingne Li, Yuhao Wang, Dingyang Wen, Xudong Liu, Wenxi Li, Hewei Liang, Xin Jin, Xun Xu, Jian Wang, Huanming Yang, Karsten Kristiansen*, Liang Xiao* & Yuanqiang Zou*.Isolation of potentially novel species expands the genomic and functional diversity of Lachnospiraceae.iMeta2024; e174.

3. Wenxi Li#, Hewei Liang#, Xiaoqian Lin#, Tongyuan Hu, Zhinan Wu, Wenxin He, Mengmeng Wang, Jiahao Zhang, Zhuye Jie, Xin Jin, Xun Xu, Jian Wang, Huanming Yang, Wenwei Zhang, Karsten Kristiansen*, Liang Xiao* &Yuanqiang Zou*.A catalog of bacterial reference genomes from cultivated human oral bacteria. npj biofilms and microbiomes. 2023. 45.

4. Xiaoqian Lin, Tongyuan Hu, Jianwei Chen, Hewei Liang, Jianwei Zhou,Zhinan Wu, Xin Jin, Xun Xu, Xiaohuan Jing, Jian Wang, Huanming Yang, Karsten Kristiansen*, Liang Xiao*,Yuanqiang Zou*. The genomic landscape of reference genomes of cultivated human gut bacteria. Nature Communications. 2023. 14:1663

5. Yuanqiang Zou#，Wenbin Xue#, Guangwen Luo#, Ziqing Deng#, Panpan Qin#, Ruijin Guo, Haipeng Sun, Yan Xia, Suisha Liang, Ying Dai, Daiwei Wan, Rongrong Jiang, Lili Su, Qiang Feng, Zhuye Jie, Tongkun Guo, Zhongkui Xia, Chuan Liu, Jinghong Yu, Yuxiang Lin, Shanmei Tang, Guicheng Huo, Xun Xu, Yong Hou, Xin Liu, Jian Wang, Huanming Yang, Karsten Kristiansen, Junhua Li*, Huijue Jia* & Liang Xiao*. 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.Nature Biotechnology. 2019, 37: 179-185.

专利

1. Yuanqiang Zou,… et al. Collinsella shenzhenensisand applications thereof. PCT/CN2016/109689 (First inventor)

2. Yuanqiang Zou,… et al. Lactobacillus gasseri, culture method therefor and application thereof. PCT/CN2016/111027 (First inventor)

3. Yuanqiang Zou,… et al. Anaerostipes caccaeand applications thereof. PCT/CN2016/109690 (First inventor)