副研究员、硕士生导师

基本情况

出生年月：1987.02

最高学位：理学博士

工作单位：深圳华大生命科学研究院

工作地址：广东省深圳市盐田区华大时空中心

Email:yinjianhua@genomics.cn

教育及工作经历

2017.05– 至今     深圳华大生命科学研究院，生物信息副研究员

2016.06– 2017.05   中科院生物物理研究所，助理研究员

2015.07– 2016.06     北京生命科学研究所，助理研究员

2010.09 – 2015.06    北京协和医学院，生物化学与分子生物学专业，理学博士

2006.09 – 2010.06     华南理工大学，生物技术专业，本科

学术兼职

山西医科大学兼职教授

研究领域及主要成果

基于单细胞组学技术的人体疾病研究

主持科研项目

1重要生命过程及疾病转录组图谱及解析，科技部国家重点研发计划项目

2基于多组学技术的脓毒症免疫功能紊乱评价标志物体系构建及靶向干预机制研究，广东省基础与应用基础研究基金项目

获奖情况

1深圳市高层次人才

2深圳市盐田区梧桐凤凰人才

代表性论文、专著和专利等（不超过10项）

(1)Jiawei Lv*, Yuan Wei*,Jian-Hua Yin*, Yu-Pei Chen*, Guan-Qun Zhou*, Chen Wei*, Xiao-Yu Liang*, Yuan Zhang*, Cui-Juan Zhang, Shi-Wei He, Qing-Mei He, Zhuo-Li Huang, Jia-Li Guan, Jia-Yi Shen, Xiao-Min Li, Jun-Yan Li, Wen-Fei Li, Ling-Long Tang, Yan-Ping Mao, Rui Guo, Rui Sun, Yu-Hui Zheng, Wen-Wen Zhou, Ke-Xu Xiong, Si-Qi Wang, Xin Jin, Na Liu, Gui-Bo Li, Dong-Ming Kuang, Ying Sun, Jun Ma(2023).The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment. Nature Medicine.29, 1424–1436. (并列第一作者)

(2)Zikun Ma, Xiangdong Li, Yize Mao, Chen Wei, Zhuoli Huang, Guibo Li,Jianhua Yin*, Xiaoyu Liang*, Zhuowei Liu* (2022). Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer. Cancer Cell.40, 1–16.(共同通讯作者)

(3)Jianhua Yin, Yingze Zhao, Fubaoqian Huang, Yunkai Yang, Yaling Huang, Zhenkun Zhuang, Yanxia Wang et al. (2022). Immune response and homeostasis mechanism following administration of BBIBP-CorV SARS-CoV-2 inactivated vaccine. The Innovation.100359, January 30, 2023

(4)Jianhua Yin,Jingzhi Lv,Shichen Yang,Yang Wang et al. (2025) Multi-omics reveals immune response and metabolic profiles during high-altitude mountaineering,Cell Reports, 2025, 44(1): 115134

(5)Zhuoli Huang, Yuhui Zheng, Weikai Wang, Wenwen Zhou, Yanbo Zhang, Chen Wei, Xiuqing Zhang, Xin Jin*, Jianhua Yin*(2024).Uncovering disease-related multicellular pathway modules on large-scale single-cell transcriptomes with scPAFA. Communications Biology 7, 1523.

(6)Yingtai Chen#, Jianhua Yin#, Lulu Zhao#, Guangyu Zhou#, Shichen Dong#, Yueming Zhang#, Penghui Niu#, Hu Ren#, Tianjiao Zheng, Juan Yan, Wenbin Li, Peiqin Ma, Cuijuan Zhang, Chen Wei, George Church, Guibo Li, Dongbing Zhao (2022). Reconstruction of the gastric cancer microenvironment after neoadjuvant chemotherapy by longitudinal single-cell sequencing. Journal of Translational Medicine.20:563.(并列第一作者)

(7)Hanlin Zhou*, Guibo Li*,Jianhua Yin*, Ting Wang*, Hong Hu*, Tong Li*, Qing Zhou, Jintao Hu, Lei Wang, Shichen Dong, Chen Wei, Cuijuan Zhang, Ye Lu, Wenbin Zhou, Chen Huang, Huanming Yang, Dongxian Zhou, Ling Wang, Kui Wu.(2021)Neoadjuvant chemotherapy alters peripheral and tumor-infiltrating immune cells in breast cancer revealed by single cell RNA sequencing.Clin Transl Med.2021;11:e62(并列第一作者)

(8) Yu-Pei Chen*,Jian-Hua Yin*, Wen-Fei Li*, Han-Jie Li*, Dong-Ping Chen*, Cui-Juan Zhang*, Jia-Wei Lv, Ya-Qin Wang, Xiao-Min Li,Jun-Yan Li, Pan-Pan Zhang, Ying-Qin Li, Qing-Mei He, Xiao-Jing Yang, Yuan Lei, Ling-Long Tang, Guan-Qun Zhou,Yan-Ping Mao, Chen Wei, Ke-Xu Xiong, Hong-Bo Zhang, Shi-Da Zhu, Yong Hou, Ying Sun, Michael Dean , Ido Amit ,Kui Wu, Dong-Ming Kuang , Gui-Bo Li , Na Liu and Jun Ma. Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma. Cell Research(2020) 30:1024–1042 (并列第一作者)

(9)Jianhua Yin, Zhifeng Wang, Guibo Li, Feng Lin, Kang Shao, Boyang Cao & Yong Hou. Characterization of circulating tumor cells in breast cancer patients by spiral microfluidics. Cell Biology and Toxicologyvolume 35, 59–66 (2019)

(10)Jianhua Yin *,Yaling Huang *, Pengfei Guo, Siqi Hu, Sawako Yoshina, Nan Xuan, Qiwen Gan, Shohei Mitani, Chonglin Yang, and Xiaochen Wang(2017). GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans.The Journal of Cell Biology. 216(6):1775-1794.