讲师、硕士导师

基本情况

出生年月：1995.12

最高学位：理学博士

工作单位：武汉理工大学，化学化工与生命科学学院

工作地址：湖北省武汉市洪山区武汉理工大学（南湖校区）化生学院

联系电话：13277050232

Email: luxiao@whut.edu.cn

教育及工作经历

2025.01 – 至今    武汉理工大学，化学专业，讲师

2022.10 – 2024.11   中国科学院大连化学物理研究所，博士后

2017.09 – 2022.06   武汉大学，有机化学专业，理学博士

2013.09 – 2017.06   湖南师范大学，化学专业，本科

学术兼职

研究领域及主要成果

主要从事有机（金属）不对称催化和基于手性药物中间体的不对称合成方法学研究

研究方向：

1.有机（金属）不对称催化构建硫手性中心的反应研究

2.基于手性药物中间体的不对称合成方法学研究

迄今在Angew. Chem., Nat. Commun., Chem. Sci.等期刊发表研究论文10余篇。

主持科研项目

1.武汉理工大学新教师科研启动基金

获奖情况

无

代表性论文、专著和专利等（不超过10项）

1.Xiao, L.; Wei, L.; Wang, C. -J.*, Stereodivergent Synthesis of Enantioenriched γ-Butyrolactones Bearing Two Vicinal Stereocenters Enabled by Synergistic Copper and Iridium Catalysis. Angew. Chem. Int. Ed. 2021,60, 24930-24940.

2.Xiao, L.^#; Li, B.^#; Xiao, F.; Fu, C.; Wei, L.; Wang, Z.-F.; Dang, Y.-F.; Dong, X.-Q.^*; Wang, C.-J.^* Dual Metal-Catalyzed Stereodivergent Synthesis of Azepino[3,4,5-cd]-Indoles via Allylation/Cationic π-Cyclization. Chem. Sci., 2022,13,4801-4812.

3.Xiao, L.^#; Chang, X.^#; Xu, H.^#; Xiong, Q.; Wang, C.-J.^*Cooperative Catalyst-Enabled Regio- and Stereodivergent Synthesis of α-Quaternary α-Amino Acids via Asymmetric Allylic Alkylation of Aldimine Esters with Racemic Allylic Alcohols. Angew. Chem. Int. Ed. 2022, 61.(10.1002/anie.202212948).

4.Xiao, L.^#; Xiong, Q.^#; Xu, H.^#; Wang, Z.-F.; Chang, X.; Dang, Y.-F.^*; Dong, X.-Q.; Wang, C.-J.^*. Cooperative Catalysis-Enabled Cascade Allylation/aza-PrinsCyclization to ChiralSpiroindolylpiperidine-γ-Butyrolactones.CCS Chem.2024, Just Published. DOI: 10.31635/ccschem.024.202404224.

5.Wei, L.^#;Xiao, L.^#; Wang, C.-J.^* Synergistic Cu/Pd Catalysis for Enantioselective Allylation of Ketimine Esters: The Direct Synthesis of α‐Substituted α‐Amino Acids and 2H‐Pyrrols.Adv. Synth. Catal.,2018,360, 4715-4719.

6.Wei, L.^#;Xiao, L.^#; Wang, Z.-F.; Tao, H.-Y.; Wang, C.-J.^*Ir/Phase-Transfer-Catalysis Cooperatively Catalyzed Asymmetric CascadeAllylation/2-aza-Cope Rearrangement: An Efficient Route to Homoallylic Amines from Aldimine Esters. Chin. J. Chem.,2020,38, 82-86.

7.Xu, S.-M.; Wei, L.; Shen, C.; Xiao, L.; Tao, H.-Y.; Wang, C.-J.^*Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction. Nat. Commun.,2019,10, 5553.

8.Wei, L.; Zhu, Q.; Xiao, L.; Tao, H.-Y.; Wang, C.-J.^*Synergistic catalysis for cascade allylation and 2-aza-cope rearrangement of azomethine ylides. Nat. Commun.,2019,10, 1594.

9.Yi, Z.-Y.; Xiao, L.; Chang, X.; Dong, X.-Q.; Wang, C.-J.^*Iridium-Catalyzed Asymmetric Cascade Allylation/Retro-Claisen Reaction. J. Am. Chem. Soc., 2022,144, 20025-20034.

10.Xiao, L. ^#; Xiong, Q. ^#; Xu, H.^#; Wang, Z.-F.; Chang, X.; Dang, Y.-F.^*; Dong, X.-Q.; Wang, C.-J.^*. Cooperative Catalysis-Enabled Cascade Allylation/aza-PrinsCyclization to ChiralSpiroindolylpiperidine-γ-Butyrolactones.CCS Chem.2025,7, 1112–1126.